Welcome to the New World of Sisneo September 2026
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Physiology Engineering Science Design
Treat the skin as a Masterpiece
Achieving real, meaningful and long-lasting results requires addressing each indication in a
comprehensive manner, leveraging the synergies that arise when different techniques and
technologies are intentionally combined to treat the same biological problem from multiple
perspectives.
This conviction has driven Sisneo to develop “The Ultimate Ecosystem”: Biological
Regeneration, Molecular Infusion, and Advanced Electrotherapy working in a coordinated
and complementary way.
These technologies allow professionals to achieve superior
outcomes that cannot be reached through isolated interventions.
No compromises Just Pure Uninhibited Excellence
Da Vinci Technology
DaVinci utilises a sophisticated array of multiple emitters to deliver controlled thermal energy into the dermal layers. It triggers a powerful bio-stimulatory response, activating endogenous regenerative processes and accelerating cellular renewal from within.
Transdermal Infusion: High-Conductance Molecular Delivery by utilising advanced electroporation, this technology creates
temporary micro-channels in the lipid bilayer, significantly
increasing skin permeability. It enables the targeted delivery of
active principles directly to the target cells, ensuring they reach
the deeper layers.
Advanced Electrotherapy: Structural Architectural Redefinition
Our integrated electrotherapy platform offers a comprehensive approach to tissue revitalisation, combining three specialised modalities designed for maximum physiological impact and clinical efficacy:
Electrobiostimulation: High-precision pulses engineered to trigger targeted cellular activation and reactivate natural metabolic processes.
Electrodrainage: Specialised bio-electric patterns that stimulate lymphatic pathways, facilitating effective detoxification and fluid mobilisation.
Electrolifting: Targeted currents designed to enhance muscular tone and dermal firmness for a visible, non-invasive contouring effect.
Integrated Phototherapy: Acts as a biological catalyst to accelerate cellular regeneration and maximise tissue comfort.
Da Vinci Hand Pieces
DaVinci offers a specialised range of hand pieces each engineered to optimise the delivery of Multipolar Tech and Transdermal Infusion through specific photonic environments.
DaVinci D3 Microliner & D6 Liner: Engineered for total accuracy in ultra-targeted topographies, such as micro-wrinkles or
delicate perioral and orbital architectures. These interfaces focus on high-accuracy electrical delivery for complex contours where pure energy precision is the clinical priority.
DaVinci D30 Acne: Specialised architecture designed for professional acne-control protocols. It incorporates a 420 nm Blue-UV
spectrum to selectively eliminate acnes bacteria through oxygen radical generation, effectively reducing lesions while providing a potent calming effect on the tissue.
DaVinci D30 Dual Wave: The universal standard for intermediate dimensions and complex facial contours. It integrates a 633 nm Red Spectrum to accelerate metabolic matrix restoration and a 590 nm Amber Spectrum to drive structural renewal through enhanced collagen and elastin production.
DaVinci D60 Dual Wave: Optimised for high-performance efficiency across macro-anatomical volumes and large body areas. This interface synchronises the 633 nm Red Spectrum for fibre regeneration with the 590 nm Amber Spectrum to restore dermal vitality and structural integrity at scale.
DaVinci P8 Dual Wave: A specialised follicular engine designed for high-conductance delivery to the hair bulb and scalp. By combining Red (633 nm) and Amber (590 nm) dual-wavelengths, it optimises the follicular environment, driving microcirculation and matrix health for superior hair-care results.
Innovation does not stop or stand still..
Welcome to our world at Sisneo Bioscience
Sisneo Bio Hacking devices break barriers and allows practitioners to Join our Eco System
We never stand still and are always working on new innovations
A New Era of Transdermal Infusion
Designed to maximise the intelligent introduction of active ingredients into the skin with absolute
Mesolux Photo-electroporation System is a medical-aesthetic device that combines transdermal electroporation with phototherapy.
MESOLUX ENABLES TWO TREATMENT TYPES:
AESTHETIC TREATMENT VIA TRANSEPIDERMAL INTRODUCTION:
Mesolux can introduce active ingredients up to 200,000Da — molecules 400 times larger than
those allowed by topical application. This dramatic increase in permeability enables results
superior even to conventional injected mesotherapy.
MEDICAL TREATMENT ENHANCING INJECTED MESOTHERAPY:
When used after injected mesotherapy (as in electrochemotherapy), electroporation
prevents systemic absorption and forces active ingredients into the targeted tissue cells.
Depending on the substance and electroporation type, efficacy increases 5 to 100 times.
Welcome to MESOLUX: mesotherapy, reinvented.
Whether used transepidermally or to enhance injected mesotherapy, electroporation
achieves results far beyond conventional techniques.
Application Methods
Mesolux can be used alone or combined with other techniques:
Option 1: Transepidermal introduction with proper skin
preparation.
Option 2: Application immediately after injected mesotherapy
to exponentially enhance the active ingredient.
Deeper more efficient and more controlled results
FOCAL PRECISION DUO™ Deliver more. Exactly where it matters.
The new Mesolux includes our Sisneo FOCAL PRECISION DUO handpieces, introduced as a powerful addition to the existing Mesolux applicators (facial, acne, capillary
and body).
These new focal handpieces integrate Bridge & Valley technology, working synergistically with Mesolux to create a high-impact delivery combo:
This allows professionals to concentrate active delivery exactly where it is needed, achieving deeper, more efficient and more controlled results.
Increased permeability in specific, targeted areas.
Greater active penetration capacity in selected tissues.
Higher amount of product effectively delivered where precision is required.
Advanced Programs & Intelligent Customisation
This level of control turns Mesolux into a
true bio-customisation platform.
Mesolux now incorporates expanded and highly configurable programs, designed to adapt to each active ingredient, treatment goal and anatomical area:
Power and pulse regulation programs, adjustable to reach different depths depending on the active being delivered.
New automated programs for Mesoactives and TDX20 delivery & focal delivery modes,
specifically developed for use with
FOCAL PRECISION DUO applicators.
Fully manual program, allowing complete parameter customisation.
Intradermal enhancement program, designed to:
Potentiate injected mesotherapy (intradermal injections).
Further enhance specific transdermal treatments.
Boost the efficacy of actives already present within the skin.